Did You Know?

 

Resveratrol (3,4′,5-trihydroxystilbene)is a phytoalexin(stilbenoids) found in many plants including grapes, peanuts, berries and knotweeds (polygonum cuspidatum). Resveratrol was first isolated in Veratrum grandiflorum, or white hellebore plant, in the 1940’s. It is present in grape berry skins but not in flesh. White wine contains very small amounts of resveratrol, compared to red wine. Potential mechanisms of resveratrol are : inhibition of synthesis and release of pro-inflammatory mediators, modification of eicosanoid synthesis, inhibition of activate immune cells and inflammatory enzymes such as iNOS and COX-2 through its inhibitory effects on NF-κB or the AP-1 signalling pathways. Resveratrol helps to reduce inflammation, lowers LDL or "bad" cholesterol, and prevents clots formation that can lead to a heart attack. Also, it protects nerve cells from damage and fights the plaque buildup that can lead to Alzheimer's. Resveratrol helps prevent insulin resistance, a condition in which the body becomes less sensitive to the blood sugar-lowering hormone insulin. The condition can lead to diabetes.

 

Whats unique?

 

One of the most striking biological activities of resveratrol is it prevents carcinogenesis in all three stages i.e initiation, promotion, and progression by directly inducing the apoptotic pathway through several mechanisms. Resveratrol is an activator of SIRT1 gene, which is believed to protect the body from various diseases and disorders. 

 

Tales of the Past

 

Resveratrol was first isolated in 1940 from white hellebore roots by the Japanese scientist Dr. Michio Takaoka. He was supervised by Dr.Riko Majima, a pioneer of Japanese organic chemistry for natural products. Dr. Kuroda identified various natural chemicals such as shikonin from a medicinal herb (Lithospermum erythrorhizon) and carthamin from safflowers. The identification of these agents as well as the identification of resveratrol by Dr. Takaoka were the first steps toward the scientific efficacy of the Chinese “material medica,” a collection of traditional Asian medicines and therapeutic foods. Further research determined that plants appeared to produce resveratrol in response to stress from injuries or diseases as a protective mechanism to limit the damage and extent of infection. In 1963, resveratrol was isolated from the roots of Polygonum cuspidatum, a plant used in the traditional medicine Ko-jo-kon4) and described as a “prescription for inflammation, carcinogenesis, and cardiovascular diseases” in “Mei-I-Betsu-Roku,” a book on materia medica published about 1500 years ago. Surprisingly, the actions described for grape and Ko-jo-kon are almost identical to those recently described for resveratrol.

 

Application in Different Health Categories

 

Cancer Therapy(Prostate, Breast, Colorectal cancer), Skin Health, Brain Health, Diabetes, Immune health, Heart Health, Liver Health.

 

Regulatory Status

 

Health Canada, FSSAI approved

 

Different Dosage Formats

 

Softgels, Sachets, Drinks, Topicals, etc

 

References

 

1.The therapeutic potential of resveratrol: a review of clinical trials by Adi Y. Berman, Rachel A. Motechin, Maia Y. Wiesenfeld and Marina K. Holz.

2. Recent Advances in the Study on Resveratrol by Rieko Nakata, Satoru Takahashi, and Hiroyasu Inoue.

3. Cardioprotection by resveratrol: A human clinical trial in patients with stable coronary artery disease by K. Magyara, R. Halmosia, A. Palf et al.